Human Myoblast Differentiation: Ca2+ Channels are Activated by K+ Channels
نویسندگان
چکیده
منابع مشابه
Human myoblast differentiation: Ca(2+) channels are activated by K(+) channels.
In a paradigm of cellular differentiation, human myoblast fusion, we investigated how a Ca(2+) influx, indispensable for fusion, is triggered. We show how newly expressed Kir2.1 K(+) channels, via their hyperpolarizing effect on the membrane potential, generate a window Ca(2+) current (mediated by alpha 1H T-type Ca(2+) channels), which causes intracellular Ca(2+) to rise.
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ژورنال
عنوان ژورنال: Physiology
سال: 2002
ISSN: 1548-9213,1548-9221
DOI: 10.1152/physiologyonline.2002.17.1.22